Healthcare provider information sheet for acinetobacter. The recent increase in incidence, largely associated with infected combat troops returning from conflict zones, coupled with a dramatic increase in the incidence of multidrugresistant mdr strains, has significantly raised the profile of this emerging opportunistic pathogen. Acinetobacter species are oxidasenegative, exhibit twitching motility, and occur in pairs under magnification they are important soil organisms, where they contribute to the mineralization of, for example, aromatic compounds. Research multidrugresistant acinetobacter baumannii. Outer membrane protein, oma87 prevents acinetobacter. Burden of multidrugresistant acinetobacter baumannii.
Prevalence of antibioticresistant acinetobacter baumannii. It can be an opportunistic pathogen in humans, affecting people with compromised immune systems, and is becoming increasingly important as a hospitalderived infection. Heres what you need to know to prevent these infections. Pathogenesis in acinetobacter baumannii by marguerite indriati hood dissertation submitted to the faculty of the graduate school of vanderbilt university in partial fulfillment of the requirements for the degree of doctor of philosophy in microbiology and. Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible for hospitalacquired nosocomial infections in the modern healthcare system. Comparison of colistin and colistinsulbactam for the. Acinetobacter baumannii can cause serious infections in the lungs, blood, and brain. Acinetobacter is notable due to its ability to become resistant to.
Healthcare provider information sheet for multidrugresistant acinetobacter baumannii mdrab division of infectious disease epidemiology dide 350 capitol street, room 125, charleston, wv 2530715 phone. Drug treatment for multidrugresistant acinetobacter. Identification of oxa23producing acinetobacter baumannii. Acinetobacter baumannii an update linkedin slideshare. Iwen, phd, associate director, nphl acinetobacter baumannii is considered the most common oxidasenegative nonfermenting gramnegative rod encounter in the clinical laboratory 1. Sequencebased comparisons classify oxacarbapenemases into eight sub groups as follows. Colistin resistance primarily occurs via modifications of the terminal phosphate moieties of lipopolysaccharidederived. This organism is widely distributed in nature and in. Acinetobacter baumannii an overview sciencedirect topics. Rao md slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Infecciones por acinetobacter baumannii panresistente. Acinetobacter baumannii has emerged in the last decades as a major cause of healthcareassociated infections. For multidrugresistant strains, antimicrobial drug selection is limited.
The genus acinetobacter comprises a complex and heterogeneous group of bacteria, many of which are capable of causing a range of opportunistic, often catheter. The current study was designed to determine whether bacteremic patients with a. To compare clinical and microbiological efficacy of colistin and colistinsulbactam for the treatment of multidrugresistant mdr acinetobacter baumannii vap in intensive care units icus. Acinetobacter baumannii secretes outer membrane vesicles omvs during both in vitro and in vivo growth, but the biogenesis mechanism by which a. You may not know that you have an acinetobacter infection until you get sick with one of the following. It is typically a short, almost round, rod shape coccobacillus. Acinetobacter baumannii can cause serious and sometimes lifethreatening infections. Acinetobacter baumannii update linkedin slideshare. It may also cause urinary tract and wound infections. Acinetobacter baumannii outer membrane protein a modulates. Outer membrane protein, oma87 prevents acinetobacter baumannii infection iraj rasooli 1,2,5 raziyeh abdolhamidi 1 abolfazl jahangiri 3 shakiba darvish alipour astaneh 4. Of the multidrugresistant organisms, the highly resistant. Acinetobacter fact sheet utah department of health. An acinetobacter baumannii infection is caused by the acinetobacter baumannii bacteria germ.
Acinetobacter baumannii infection what you need to know. Acinetobacter baumannii is a prevalent nosocomial pathogen with a high incidence of multidrug resistance. Nonventilated patients with hap nvhap caused by nosocomial pathogens are reported to have a more favorable outcome than those with ventilatorassociated pneumonia vap. A prospective study of acinetobacter baumannii complex. Acinetobacter baumannii is a typically short, almost round, rodshaped coccobacillus gramnegative bacterium. Facilityspecific results were provided to participating facilities, and aggregate survey results were shared with acute care hospitals. A significant number of additional cases have been found in the canadian and british armed forces, and among wounded iraqi civilians. Overall, 34% of patients surveyed were positive for a. This germ may be found on skin or in food, water, or soil. This organism is often cultured from hospitalized patients sputum or respiratory. Acinetobacter baumannii is an opportunistic bacterial pathogen primarily associated with hospitalacquired infections. Characteristics of multidrugresistant acinetobacter.
In this retrospective analysis, patients 16 yearsold who received iv colistin or colistinsulbactam for the treatment of mdr a. Acinetobacter baumannii infection aftercare instructions. However, acinetobacter baumannii, as well as its close relatives belonging to genomic species 3 acinetobacter pittii and tu acinetobacter nosocomialis, are important nosocomial pathogens. Acinetobacter is a genus of gramnegative bacteria belonging to the wider class of gammaproteobacteria. Acinetobacter baumannii is an oxidasenegative and strictly aerobic gramnegative coccobacillary rod that grows at 20 to 30. Summary carbapenemresistant gramnegative bacteria, in particular the acineto bacter baumannii calcoaceticus complexandenterobacteriaceae,areescalatingglobal public health threats. It can be an opportunistic pathogen in humans, affecting people with compromised immune systems and is becoming increasingly important as a hospital derived infection nosocomial. Acinetobacter baumannii is a pleomorphic aerobic gramnegative bacillus similar in appearance to haemophilus influenzae on gram stain commonly isolated from the hospital environment and hospitalized patients. Acinetobacter baumannii is an aerobic, nonfermentative, gramnegative, nonmotile, coccobacilli harboring a number of effective virulence factors. These bacteria are most often spread persontoperson in healthcare settings through. Acinetobacter baumannii is a bacterium that can cause a range of diseases. A baumannii is a water organism and preferentially colonizes aquatic environments. If you continue browsing the site, you agree to the use of cookies on this website. In most regions, the acinetobactor baumannii group was the most frequently isolated genospecies.
Clinical antibioticresistant acinetobacter baumannii. It typically infects people inside a healthcare facility doctors refer to these as nosocomial infections. But in ireland and germany, acinetobacter genospecies 3 was found to be the most predominant genospecies. February 2011, 73 pages carbapenem resistance in acinetobacter baumannii is a growing public health concern and represents a serious problem for treatment of the infection. Occurrence of bla gene in imipenemsusceptible oxa23. The genospecies of clinical isolates of the acinetobacter baumannii group may vary considerably. Acinetobacter baumannii acinetobacter baumannii is a gram negative bacteria. It has recently emerged as a major cause of hai because of its propensity to accumulate mechanisms of. Acinetobacter baumannii and antimicrobial discovery. Acinetobacter baumannii, a gramnegative opportunistic coccobacilli, has emerged globally in healthcare institutions because it is hard to eradicate, most likely because it is resistant to desiccation and to ultraviolet and chemical sanitizers. Acinetobacter baumannii hospitalacquired pneumonia hap is associated with a high mortality worldwide.
To overcome this problem, knowledge of the pathogenesis. Optimal therapy for multidrugresistant acinetobacter. Due to the prevalence of infections and outbreaks caused by multidrug resistant a. Acinetobacter infection an emerging threat to human. Acinetobacter baumannii infections in iraq war since operation iraqi freedom began in 2003, more than 700 us soldiers have been infected or colonized with acinetobacter baumannii. Antibioticresistant acinetobacter baumannii is associated with nosocomial infections worldwide. In addition to causing severe disease in hospitalized patients, a. Acinetobacter baumannii is a common pathogen isolated in u. Treatment of infections due to this organism with colistin, a lastresort antibiotic of the polymyxin class, can result in the emergence of colistinresistant strains. Isolation and identification of acinetobacter baumannii.
1574 1105 130 391 1144 137 162 1409 65 44 636 1258 1542 1514 1471 1497 86 37 185 465 1086 282 984 91 1235 1113 827 803 1295 1096 441 214 284 1590 256 386 465 1349 1434 915 745 675 1354